CALL FOR PAPERS Novel Mechanisms and Roles of Glomerular Podocytes Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney
نویسندگان
چکیده
Tarak Srivastava, Uri S. Alon, Patricia A. Cudmore, Belal Tarakji, Alexander Kats, Robert E. Garola, R. Scott Duncan, Ellen T. McCarthy, Ram Sharma, Mark L. Johnson, Lynda F. Bonewald, Ashraf El-Meanawy, Virginia J. Savin, and Mukut Sharma Section of Nephrology, Children’s Mercy Hospital and University of Missouri-Kansas City, Kansas City, Missouri; Department of Pathology and Laboratory Medicine, Children’s Mercy Hospital and University of Missouri-Kansas City, Kansas City, Missouri; Section of Infectious Diseases, Children’s Mercy Hospital and University of Missouri-Kansas City, Kansas City, Missouri; Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; Renal Research Laboratory, Research and Development, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri; Department of Oral Biology, University of Missouri-Kansas City School of Dentistry, Kansas City, Missouri; and Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin
منابع مشابه
Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney.
Hyperfiltration subjects podocytes to increased tensile stress and fluid flow shear stress (FFSS). We showed a 1.5- to 2.0-fold increase in FFSS in uninephrectomized animals and altered podocyte actin cytoskeleton and increased synthesis of prostaglandin E2 (PGE2) following in vitro application of FFSS. We hypothesized that increased FFSS mediates cellular changes through specific receptors of ...
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